Metabolism of L-Thyroxine and L-Triiodothyronine in the Absence of the Liver
- 30 November 1956
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 187 (3), 407-414
- https://doi.org/10.1152/ajplegacy.1956.187.3.407
Abstract
The total amount of I131-containing compounds excreted in the urine of the dehepatized dog receiving either radioactive thyroxine or triiodothyronine is similar to that of the normal dog receiving similar injections. The important role of the liver in the deiodination of thyroxine and triiodothyronine is indicated by the failure of the liverless animal to convert these compounds to inorganic iodide as completely as does the normal dog. Only a small percentage of the I131 compounds excreted by the liverless dog appears as inorganic iodide. The most abundant iodine compound in the urine of the dehepatized dog is a conjugate of thyroxine when thyroxine is injected, and an unidentified compound, b, when triiodothyronine is injected.Keywords
This publication has 9 references indexed in Scilit:
- Lack of Synergistic Relationship Between Thyroid and Salivary Gland FunctionExperimental Biology and Medicine, 1955
- A QUANTITATIVE METHOD FOR THE SEPARATION OF THE IODINATED AMINO ACIDS OF THYROID TISSUE1Endocrinology, 1954
- The effect of emotional and physical stress on thyroid activity in the rabbitThe Journal of Physiology, 1954
- In vitro Conversion of Thyroxin to Triiodothyronine by Kidney Slices.Experimental Biology and Medicine, 1954
- 3:5:3′-Triiodothyronine. 1. Isolation from thyroid gland and synthesisBiochemical Journal, 1953
- Metabolism of I131-Labeled Thyroxine—Studies With Isolated, Perfused Rat LiverAmerican Journal of Physiology-Legacy Content, 1953
- Sur l'excrétion biliaire et la glycuroconjugaison de la 3:5:3′-triiodothyronineBiochimica et Biophysica Acta, 1953
- THE ROLE OF THE GASTROINTESTINAL TRACT, INCLUDING THE LIVER, IN THE METABOLISM OF RADIOTHYROXINE*Endocrinology, 1952
- Chromatographie quantitative des acides aminés iodés radioactifs de la thyroglobuline marqueéeBiochimica et Biophysica Acta, 1951