A large domain common to sperm receptors (Zp2 and Zp3) and TGF‐β type III receptor
- 6 April 1992
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 300 (3), 237-240
- https://doi.org/10.1016/0014-5793(92)80853-9
Abstract
A new family of mosaic proteins is defined by sequence analysis. The family is characterized by a 260 residue domain common to proteins of apparently diverse function and tissue specificity; sperm receptors Zp2 and Zp3, betaglycan (also called TGF-β type III receptor), uromodulin, as well as the major zymogen granule membrane protein (GP-2). The location of the common domain is similar with respect to putative transmembrane regions. The results lead to the hypothesis that this type of domain has a common tertiary structure and that there is a functional similarity in the recognition mechanism of the sperm receptor system and the TGF-β receptor complex.Keywords
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