Interaction Between the Guanine Amino Group and the Adenine Six Membered Ring Stabilizes the Unusual Conformation of the CpA Step in B-DNA
- 1 September 1994
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 13 (8), 1669-1677
- https://doi.org/10.1080/15257779408009472
Abstract
The CpA step is dramatically overwound in several B-DNA oligonucleotide crystal structures and its AT pair is substantially shifted towards the cytosine of the preceding base pair and towards the minor groove. We show using a geometrical analysis of the crystal data and empirical potential calculations that a strong interaction between the guanine amino group and the adenine six membered ring is responsible for the unique conformational properties of the CpA step.Keywords
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