A Serologic Study of Chorionic Gonadotrophin

Abstract

Summary 1. Seventeen rabbits were immunized with “APL,” which is a combined extract of human placental tissue and pregnancy urine. Seven rabbits (6 females) produced detectable antibodies. 2. Two hundred eighty-five urines submitted for pregnancy tests were tested for the presence of CG by biological and serological methods. 3. Sative rabbit CG antiserum tends to give many cross-reactions. Therefore, it is necessary to absorb the serum and test it for potency and specificity prior to use in testing urines for the presence of increased amounts of CG. 4. It is suggested that it may be possible to use this serologic method for the detection of pregnancy; the development of an antiserum of somewhat greater specificity would be advantageous.