Malabsorption of Vitamin B12 in Diabetic Patients Treated with Phenformin: A Comparison with Metformin
- 29 September 1973
- Vol. 3 (5882), 673-675
- https://doi.org/10.1136/bmj.3.5882.673
Abstract
An investigation into B12 absorption in diabetic patients on long-term phenformin therapy was undertaken and the results were compared to a similar investigation previously reported in diabetics on long-term metformin. Forty-six per cent of patients were found to have B12 malabsorption as shown by abnormal results of Schilling tests. The mechanism of B12 malabsorption is unknown but it is suggested that all patients on long-term phenformin therapy should, like the patients on metformin, have annual serum B12 estimations until the results of a longer follow-up series are known.Keywords
This publication has 9 references indexed in Scilit:
- Vitamin-B12 Status of Patients on Long-term Metformin TherapyBMJ, 1971
- Studies on the Site and Mechanism of Action of Phenformin: II. Phenformin Inhibition of Glucose Transport by Rat IntestineDiabetes, 1970
- Studies on the Site and Mechanism of Action of Phenformin: I. Evidence for Significant “Nonperipheral” Effects of Phenformin on Glucose Metabolism in Normal SubjectsDiabetes, 1970
- Intestinale Absorptionsstörung infolge metforminbehandlung (Zur Frage der Wirkungsweise der Bignanide)Diabetologia, 1969
- Absorption, distribution in the organism and elimination of metforminDiabetologia, 1969
- THE FATE OF BIGUANIDES IN MANAnnals of the New York Academy of Sciences, 1968
- CHANGES IN THE BLOOD AFTER PARTIAL GASTRECTOMY WITH SPECIAL REFERENCE TO VITAMIN B12I. Serum Vitamin B12 Haemoglobin, Serum Iron, and Bone MarrowQJM: An International Journal of Medicine, 1961
- Studies on the folic acid activity of human serumJournal of Clinical Pathology, 1961
- The Measurement of Folic Acid Activity in Serum: A Diagnostic Aid in the Differentiation of the Megaloblastic AnemiasBlood, 1960