Functional Properties of Isolated Hepatocytes From Ethanol–Treated Rat Liver

Abstract

Gluconeogenesis and palmitate incorporation into triacylglycerols and phosphatidylcholine were measured in isolated hepatocytes from control and ethanol–treated rats. Basal gluconeogenesis and its hormonal response decreased in hepatocytes from ethanol–treated animals; palmitate incorporation into triacylglycerols increased. In ethanol–treated rat liver, ⁴⁵Ca²⁺ uptake and methylating capacity were reduced, and the hormonal response exhibited differences in binding parameters of insulin.