Development of cerebellar malignant astrocytoma at site of a medulloblastoma treated 11 years earlier

Abstract

A child treated with radiotherapy and surgery for a desmoplastic medulloblastoma of the left cerebellar hemisphere at the age of 10 mo. developed a malignant astrocytoma in the same site 11 yr later. Theories of origin of the 2nd tumor, particularly in relation to concepts of the genesis of medulloblastoma in general, are discussed.