Potential Influence of Body Weight on the Clearance of Polymorphically Acetylated Drugs
- 6 May 1982
- journal article
- research article
- Published by Wiley in The Journal of Clinical Pharmacology
- Vol. 22 (5-6), 271-275
- https://doi.org/10.1002/j.1552-4604.1982.tb02673.x
Abstract
The acetylation clearance of sulfamethazine was found to be significantly dependent upon body weight in both intermediate and rapid acetylators. The correlation beween acetylation clearance and body weight was stronger in the rapid acetylator. It is recommended that weight‐corrected acetylation clearance values be used when constructing distribution histograms for phenotyping purposes. Within a phenotypic mode, body weight may be useful in providing initial estimates of dosing needs.This publication has 19 references indexed in Scilit:
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