A unique set of polypeptides is induced by γ interferon in addition to those induced in common with α and β interferons
- 1 February 1983
- journal article
- Published by Springer Nature in Nature
- Vol. 301 (5899), 437-439
- https://doi.org/10.1038/301437a0
Abstract
Human immune interferon (IFN-gamma) differs from leukocyte interferon (IFN-alpha) and fibroblast interferon (IFN-beta) in cell origin, inducing agents, physical and biological properties and amino acid sequence. These differences have led to interest in possible differences in the biological properties of IFN-gamma compared with IFN-alpha and IFN-beta. IFN-gamma has the same broad range of biochemical and biological actions as do IFN-alpha and IFN-beta, although relative potencies vary depending on the cell type and function investigated. There has so far been no direct evidence that IFN-gamma alters normal cell functions differently from other interferons. We report here striking qualitative and quantitative differences in the intracellular response of human fibroblasts to IFN-gamma compared with IFN-alpha and IFN-beta. Two-dimensional gel electrophoresis demonstrates, in addition to the induction of a common group of polypeptides, the existence of a set of polypeptides whose synthesis is uniquely induced by IFN-gamma.Keywords
This publication has 14 references indexed in Scilit:
- Direct evidence that the gene product of the human chromosome 21 locus, IFRC, is the interferon-α receptorBiochemical and Biophysical Research Communications, 1982
- Expression of human immune interferon cDNA in E. coli and monkey cellsNature, 1982
- High affinity binding of 125I-labeled mouse interferon to a specific cell surface receptor II. Analysis of binding propertiesVirology, 1981
- Evidence that types I and II interferons have different receptorsNature, 1981
- Differential efficacies of human type I and type II interferons as antiviral and antiproliferative agents.Proceedings of the National Academy of Sciences, 1980
- Antiviral response and induction of specific proteins in cells treated with immune T (type II) interferon analogous to that from viral interferon (type I)-treated cellsVirology, 1980
- Mouse fibroblast (type I) and immune (type II) interferons: pronounced differences in affinity for gangliosides and in antiviral and antigrowth effects on mouse leukemia L-1210R cells.Proceedings of the National Academy of Sciences, 1980
- Synthesis of Interferon-Induced Polypeptides in Normal and Chromosome 21-Aneuploid Human Fibroblasts: Relationship to Relative Sensitivities in Antiviral AssaysJournal of Interferon Research, 1980
- Action of Murine γ (Immune)interferon on β (Fibroblast)-Interferon Resistant L 1210 and Embryonal Carcinoma CellsJournal of Interferon Research, 1980
- THE LINKAGE OF GENES FOR THE HUMAN INTERFERON-INDUCED ANTIVIRAL PROTEIN AND INDOPHENOL OXIDASE-B TRAITS TO CHROMOSOME G-21The Journal of Experimental Medicine, 1973