Prophylaxis for Postoperative Deep-Vein Thrombosis
- 5 January 1979
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 241 (1), 39-42
- https://doi.org/10.1001/jama.1979.03290270029015
Abstract
Randomized clinical trials in 300 patients undergoing major abdominal surgery or hip replacement arthroplasty were performed to investigate the efficacy of dihydroergotamine mesylate, heparin calcium, or a combination of dihydroergotamine with heparin in preventing postoperative deep-vein thrombosis (DVT). The diagnosis of DVT was established by an uptake test using fibrinogen labeled with iodine 125; in patients undergoing hip replacement, phlebography was also employed to confirm or refute the presence of isotopic thrombi. The data indicate that the combination of dihydroergotamine and heparin is more effective than heparin or dihydroergotamine alone in preventing DVT. (JAMA241:39-42, 1979)Keywords
This publication has 3 references indexed in Scilit:
- Studies on the peripheral mode of action of dihydroergotamine in human and canine veinsEuropean Journal of Pharmacology, 1974
- The Diagnosis of Deep Vein Thrombosis Using the 125I Fibrinogen TestArchives of Surgery, 1972
- Comparative Effects of Dihydroergotamine and Noradrenaline on Resistance, Exchange and Capacitance Functions in the Peripheral CirculationClinical Science, 1970