Erythropoietin: Production by a Particulate Fraction of Rat Kidney
- 29 April 1966
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 152 (3722), 653-654
- https://doi.org/10.1126/science.152.3722.653
Abstract
An erythropoietic factor was extracted with hypotonic phosphate buffer from the kidneys of hypoxic rats. Normal rat serum enhanced the activity of this factor, which is associated with the light mitochondrial fraction. The data suggest that the renal factor is not physiologically active unless it interacts with a serum carrier or activator, or that the factor may be an enzyme which produces erythropoietin from some serum substrate.This publication has 8 references indexed in Scilit:
- Extraction of Erythropoietin from Kidneys of Hypoxic and Phenylhydrazine-Treated RatsBlood, 1965
- CHEMICAL + BIOLOGIC PROPERTIES OF ERYTHROPOIETIN-GENERATING SUBSTANCE OBTAINED FROM PERFUSATES OF ISOLATED ANOXIC KIDNEYS1964
- Subcellular fractionation of bovine posterior pituitary glands by centrifugationArchives of Biochemistry and Biophysics, 1963
- USE OF HYPOXIA-INDUCED POLYCYTHEMIC MOUSE IN ASSAY AND STANDARDIZATION OF ERYTHROPOIETIN1963
- Enzymic actions on the human urinary erythropoietic-stimulating factorBiochimica et Biophysica Acta, 1960
- CONCENTRATION OF ACID PHOSPHATASE, RIBONUCLEASE, DESOXYRIBONUCLEASE, ß-GLUCURONIDASE, AND CATHEPSIN IN "DROPLETS" ISOLATED FROM THE KIDNEY CELLS OF NORMAL RATSThe Journal of cell biology, 1956
- ISOLATION AND BIOCHEMICAL PROPERTIES OF DROPLETS FROM THE CELLS OF RAT KIDNEYJournal of Biological Chemistry, 1954