Individually repressible enzymes specified by clustered genes of arginine synthesis.

Abstract

In Escherichia coli, K12, the repression by arginine of acetylornithinase and arginino-succinase, which correspond to clustered genes, is noncoordinate and is governed by the Rarg gene. In the K12 derivative of Pittard et al., in which the genes specifying the two enzymes have become separated through a rearrangement, the repression behavior of these enzymes is essentially unchanged. Individual repressor recognition sites are thus indicated to be involved in the regulation of the synthesis of these enzymes, both in strains with normal gene order and in strains with rearranged gene order.