Patterns of adrenergic and peptidergic innervation in human olfactory mucosa: Age‐related trends
- 1 August 1993
- journal article
- research article
- Published by Wiley in Journal of Comparative Neurology
- Vol. 334 (1), 104-116
- https://doi.org/10.1002/cne.903340109
Abstract
The distribution and targets of nerves containing the adrenergic markers tyrosine hydroxylase, dopamine β-hydroxylase, and neuropeptide Y in the human olfactory mucosa were investigated by immunohistochemistry. Tissue was obtained at autopsy from the nasal cleft of 16 adults ranging in age from 24 to 90 years, and from one spontaneously aborted 16-week-old fetus. The presence of olfactory receptor neurons in nasal mucosa was confirmed by staining with the antibody to olfactory marker protein. Targets of adrenergic innervation were blood vessels, including the vasa nervorum within the sheaths of olfactory nerve bundles, and Bowman's glands in the lamina propria. Adrenergic fibers penetrated the adventitia of blood vessels and terminated near the media, and were in close proximity to Bowman's glands but did not enter the acini. In the fetal tissue, the vasa nervorum were the major targets of adrenergic fibers. Age-related differences in the pattern and statistically significant differences in the density of innervation of blood vessels were noted between adults under and over 60 years of age. In the younger group, plexuses of nerve fibers containing colocalized dopamine β-hydroxylase and neuropeptide Y occurred adjacent to arterioles and large bundles of fibers adjacent to venules; in older individuals, few fiber plexuses occurred adjacent to arterioles and thin bundles of fibers adjacent to venules. The distribution of adrenergic innervation suggests that vasomotor tone and secretion are regulated by adrenergic nerves. The decrease in adrenergic innervation in older individuals, with resultant effects on perireceptor processes, may be associated with age-related declines in olfactory function.Keywords
This publication has 55 references indexed in Scilit:
- Immunohistochemical localization of components of the immune barrier in the olfactory mucosae of salamanders and ratsThe Anatomical Record, 1991
- Delineation of olfactory pathways in the frog nervous system by unique glycoconjugates and N-CAM glycoformsNeuron, 1991
- Regulatory Peptides and General Neuroendocrine Markers in Human Nasal Mucosa, Soft Palate and LarynxActa Oto-Laryngologica, 1991
- MeetingsJournal Of Hypertension, 1990
- Neurochemical Aspects of Dementia DisordersDementia and Geriatric Cognitive Disorders, 1990
- Pathological changes in olfactory neurons in patients with Alzheimer's diseaseNature, 1989
- Immunoreaktives Somatostatin im peripheren olfaktorischen System und in der Nasenschleimhaut des Menschen*, **Laryngo-Rhino-Otologie, 1989
- The fine structure of the olfactory mucosa in manJournal of Neurocytology, 1982
- Development and ageing of perivascular adrenergic nerves in the rabbit. A quantitative fluorescence histochemical study using image analysisJournal of the Autonomic Nervous System, 1982
- The central adrenergic system. An immunofluorescence study of the location of cell bodies and their efferent connections in the rat utilizing dopamine‐B‐hydroxylase as a markerJournal of Comparative Neurology, 1975