Endogenous induction of the galactose operon in Escherichia coli K12.
- 1 March 1966
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 55 (3), 622-629
- https://doi.org/10.1073/pnas.55.3.622
Abstract
Endogenous induction of the galactose operon in galactokinaseless mutants of E. coli K12 has been examined. It has been found that this pleiotropic phenomenon depends not only on a defective galactoklnase, but also on additional factors. An unimpaired UDP-glucose/UDP-galactose pathway is a prerequisite for the formation of endogenous inducer. This is borne out by the fact that galactokln-aseless mutants with an additional defect of either UDPG pyrophosphorylase or UDPGal-4-epimerase lose their constitutivity of the galactose operon. An efficient retention mechanism for the endogenous inducer seems also to be of importance in the manifestation of endogenous induction.This publication has 15 references indexed in Scilit:
- Imidazolepropionate, a Nonmetabolizable Inducer for the Histidine-degrading Enzymes in Aerobacter aerogenesJournal of Biological Chemistry, 1965
- Mutations in Escherichia coli that affect uridine diphosphate glucose pyrophosphorylase activity and galactose fermentationBiochimica et Biophysica Acta, 1963
- A CHEMICAL BASIS FOR THE HOST-INDUCED MODIFICATION OF T-EVEN BACTERIOPHAGESProceedings of the National Academy of Sciences, 1963
- HOST-INDUCED MODIFICATION OF T-EVEN PHAGES DUE TO DEFECTIVE GLUCOSYLATION OF THEIR DNAProceedings of the National Academy of Sciences, 1963
- Mécanismes régulateurs dans la biosynthèse des enzymes du métabolisme du galactose chez Escherichia coli K12Journal of Molecular Biology, 1963
- BIOCHEMICAL OBSERVATIONS ON E. COLI MUTANTS DEFECTIVE IN URIDINE DIPHOSPHOGLUCOSEProceedings of the National Academy of Sciences, 1962
- A method for isolating constitutive mutants for carbohydrate-catabolizing enzymesBiochimica et Biophysica Acta, 1962
- Separate permeases for the accumulation of methyl-β-D-galactoside and methyl-β-D-thiogalactoside in Escherichia coliBiochimica et Biophysica Acta, 1959
- HEREDITARY DEFECTS IN GALACTOSE METABOLISM IN ESCHERICHIA COLI MUTANTS, I. DETERMINATION OF ENZYME ACTIVITIESProceedings of the National Academy of Sciences, 1959
- ENZYME INDUCTION AS AN ALL-OR-NONE PHENOMENONProceedings of the National Academy of Sciences, 1957