SHV-13, a Novel Extended-Spectrum β-Lactamase, in Klebsiella pneumoniae Isolates from Patients in an Intensive Care Unit in Amsterdam
- 1 April 2000
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 44 (4), 1081-4
- https://doi.org/10.1128/aac.44.4.1081-1084.2000
Abstract
Eleven clonally related Klebsiella pneumoniae isolates were examined. These had been isolated at an intensive care unit in Amsterdam in 1994. Their resistance was associated with a conjugative 170-kb plasmid which encoded a novel SHV β-lactamase designated SHV-13. The SHV-13 enzyme had two substitutions compared with SHV-1: Leu35Gln and Gly238Ala. It hydrolyzed cefotaxime much more rapidly than ceftazidime or aztreonam.Keywords
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