Chronic exercise training alters kinetic properties of rat skeletal muscle and myocardial lactate dehydrogenase
- 2 November 1986
- journal article
- Published by Wiley in FEBS Letters
- Vol. 208 (2), 297-300
- https://doi.org/10.1016/0014-5793(86)81036-5
Abstract
10 weeks of treadmill running dramatically altered the kinetic properties of lactate dehydrogenase (EC 1.1.1.27) in skeletal muscle and myocardium in the rat. These changes, including V max, K m and optimal concentrations for pymvate and lactate, indicate that exercise training induces the formation of H-isozyme in skeletal muscle and M-isozyme in the heart and represent metabolic adaptations of these tissues to chronic aerobic exercise.Keywords
This publication has 16 references indexed in Scilit:
- Enzymatic adaptation to physical training under beta-blockade in the rat. Evidence of a beta 2-adrenergic mechanism in skeletal muscle.JCI Insight, 1986
- Lactate dehydrogenase isozymes in type I, IIA and IIB fibres of rabbit skeletal musclesHistochemistry and Cell Biology, 1984
- Effects of physical training on several glycolytic enzymes in rat heartBiochimica et Biophysica Acta (BBA) - General Subjects, 1975
- Lactate dehydrogenase subunit and activity changes in hypertrophied heart of the hypoxically exposed ratBiochimica et Biophysica Acta (BBA) - Enzymology, 1974
- Lactate dehydrogenase and pyruvate kinase in rat heart during sideropenic anemiaBiochimica et Biophysica Acta (BBA) - Enzymology, 1974
- UV-Assay with Pyruvate and NADHPublished by Elsevier ,1974
- Regulatory characteristics of lactate dehydrogenasesAdvances in Enzyme Regulation, 1972
- Functions of the Two Forms of Lactic Dehydrogenase in the Breast Muscle of BirdsNature, 1963
- EVOLUTION AND DIFFERENTIATION OF DEHYDROGENASES*Annals of the New York Academy of Sciences, 1961
- Molecular Heterogeneity and Evolution of EnzymesScience, 1960