Effect of Anti-ulcer Drugs on Gastric Mucous Hexosamine in Rats subjected to Several Ulcerogenic Conditions

Abstract

Hexosamine content of pyloric tissue of the stomach in rats exposed to fasting, water immersion and restraint stress, and cortisone treatment was determined. Water immersion and restraint stress, and cortisone treatment resulted in the decreased hexosamine content. Anti-ulcer drugs were administered to these animals orally. In the water immersion and restraint stress the hexosamine content of pyloric tissue of the rats was increased by tyrosine, threonine, glutamine, gefarnate, synthetic aluminum silicate and sodium copper chlorophylline. Glutamine, gefarnate and sodium copper chlorophylline also induced the increase in hexosamine content of the rat pyloric tissue treated with cortisone acetate.