Plasma prednisolone levels in man following administration in plain and enteric-coated forms.
- 1 June 1977
- journal article
- research article
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 4 (3), 351-355
- https://doi.org/10.1111/j.1365-2125.1977.tb00723.x
Abstract
1 Prednisolone plasma levels were measured in seven patients by a competitive protein binding method after administration of prednisolone (20 mg) by mouth as plain or enteric-coated tablets. 2 The mean peak plasma prednisolone concentration after the enteric-coated preparation, 199 ng ml-1, was significantly lower than after the plain tablet, 268 ng ml-1, and occurred later, at 4.69 h compared with 1.72 h. The bioavailability of the two preparations was similar. 3 It is concluded that, although the plasma concentration versus time profiles are different, the absorption of prednisolone from plain and enteric-coated preparations is equal.Keywords
This publication has 10 references indexed in Scilit:
- Absorption of enteric and non-enteric coated prednisolone tablets.British Journal of Clinical Pharmacology, 1975
- Measurement of plasma prednisolone in man.British Journal of Clinical Pharmacology, 1975
- Patterns of plasma levels of prednisolone after oral administration in manJournal of Pharmacokinetics and Biopharmaceutics, 1974
- A Competitive Protein Binding Method for Plasma Prednisolone AssayAnnals of Clinical Biochemistry: International Journal of Laboratory Medicine, 1974
- Prevention of Peptic Ulceration During Corticosteroid TherapyBMJ, 1959
- STEROID THERAPY AND PEPTIC ULCERATIONThe Lancet, 1959
- Response of Infants to a Third Dose of Poliomyelitis Vaccine Given 10 to 12 Months after Primary ImmunizationBMJ, 1959
- Peptic ulcer in rheumatoid patients on corticosteroid therapy. A clinical, experimental and radiologic studyArthritis & Rheumatism, 1958
- Effects of Prolonged Adrenocortical Stimulation on Patients with Rheumatoid ArthritisAnnals Of The Rheumatic Diseases, 1957
- The problem of peptic ulcerAmerican Journal Of Medicine, 1952