An HLA‐All Assoiciation with the hemochromatosis allele?
- 1 September 1983
- journal article
- research article
- Published by Wiley in Clinical Genetics
- Vol. 24 (3), 171-176
- https://doi.org/10.1111/j.1399-0004.1983.tb02234.x
Abstract
Two hundred and seventy‐four patients with hemochromatosis and 1005 controls were HLA typed, and HLA haplotypes were determined for 163 patients and 123 controls. The increased frequency of antigen A3 and haplotypes A3, B7 and A3, B14 in patients with hemochromatosis was confirmed. After correction for the space taken up by A3, a significant increase in All was found. This increase could not be explained by cross reaction between A3 and All. All showed a phenotype association and a haplotype link with Bw35. The genetic significance of this increased All frequency is discussed.Keywords
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