Bone Scanning with85Sr,87mSr and18F. Physical and Radiopharmaceutical Considerations and Clinical Experience in 50 Cases

Abstract

Physical and radiopharmaceutical considerations showed that short-lived isotopes can be used to scan with reduced radiation dose. Simple methods of producing 87mSr and 18F in a nuclear reactor, and of preparing them for injection are described. 87mSr, has certain physiological advantages especially when scanning the pelvis. The choice of time interval was discussed. With 87mSr the best scans were obtained approximately 1 hr. after administration. Clinically, the cases fall into 3 groups. First, primary neoplasms; there are 8 of these. Demonstrable adjacent bony involvement in connection with a soft tissue malignant tumor (e.g. Pancoast''s tumor) will affect the approach to treatment. Secondly, 38 cases of metastic bone lesions were analyzed in relation to radiographic changes. Positive scans influence the decision concerning treatment of the primary lesion if not already initiated. Scanning gives a more accurate and earlier assessment of radiotherapy field size than does the radiograph in both primary and secondary bony lesions. Negative scans give reassurance to patient and clinician. The 3rd group consists of bony dystrophies and infective lesions. One case in which a sarcoma had developed is common to the 1st group.