The effects of Na+ channel blockers on somatosensory processing by rat dorsal horn neurones
- 1 May 1997
- journal article
- research article
- Published by Wolters Kluwer Health in NeuroReport
- Vol. 8 (7), 1549-1554
- https://doi.org/10.1097/00001756-199705060-00001
Abstract
TWO voltage-activated Na+ channel blockers, lamotrigine and flunarizine were applied ionophoretically to extracellularly recorded dorsal horn neurones to assess effects on activation by noxious (mustard oil) and innocuous (brush) stimuli. Lamotrigine and flunarizine caused significantly greater reductions in mustard oil-evoked activity (> 50% in both cases) than in brush-evoked activity (13 ± 7% and 29 ± 6%; p < 6%; ± 0.005 and p < 0.05 respectively) at equivalent ionophoretic currents. Similar results were observed when lamotrigine was administered i.v. Thus, the activation of dorsal horn neurones by nociceptive and non-nociceptive afferent inputs can be differentiated by the blockade of a lamotrigine/flunarizine-sensitive Na+ channel, at a spinal site.Keywords
This publication has 13 references indexed in Scilit:
- Lignocaine selectively reduces C fibre-evoked neuronal activity in rat spinal cord in vitro by decreasing N -methyl-D-aspartate and neurokinin receptor-mediated post-synaptic depolarizations; implications for the development of novel centrally acting analgesicsPain, 1996
- A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neuronsNature, 1996
- Effect of lamotrigine on the electrically-evoked release of endogenous amino acids from slices of dorsal horn of the rat spinal cordNeuropharmacology, 1995
- Effect of lamotrigine in the acute and chronic hyperalgesia induced by PGE2 and in the chronic hyperalgesia in rats with streptozotocin-induced diabetesPain, 1995
- Studies on the mechanism of action of the novel anticonvulsant lamotrigine (Lamictal) using primary neuroglial cultures from rat cortexBrain Research, 1993
- Flunarizine inhibits both calcium-dependent and -independent release of glutamate from synaptosomes and cultured neuronesBrain Research, 1993
- An in vitro investigation of the action of lamotrigine on neuronal voltage-activated sodium channelsEpilepsy Research, 1992
- Evidence for involvement ofN-methylaspartate receptors in ‘wind-up’ of class 2 neurones in the dorsal horn of the ratBrain Research, 1987
- Common modes of drug action on Na+ channels: local anesthetics, antiarrhythmics and anticonvulsantsTrends in Pharmacological Sciences, 1987
- Evidence for a central component of post-injury pain hypersensitivityNature, 1983