5-hydroxytryptamine: source of activator calcium in human basilar arteries.
- 30 June 1985
- journal article
- research article
- Published by Wolters Kluwer Health in Stroke
- Vol. 16 (4), 718-720
- https://doi.org/10.1161/01.str.16.4.718
Abstract
We performed experiments in human cerebral arteries to determine the source of activator calcium during contractions induced by 5-hydroxytryptamine. Rings of human basilar artery obtained at autopsy were mounted for isometric tension recording in organ baths filled with a physiological salt solution. Contractile responses to 5-hydroxytryptamine were virtually abolished in Ca++-free solution, and inhibited significantly by nimodipine. In both cases, the depression of the response to 5-hydroxytryptamine was comparable to that seen when KCl was used to contract the vessels. These experiments demonstrate that 5-hydroxytryptamine mediates contraction of the smooth muscle in human basilar artery by increasing membrane permeability to extracellular calcium.This publication has 15 references indexed in Scilit:
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