Role of Calmodulin/Protein Kinase C in Interferon Production by Poly(rl) · Poly(rC) in Primed Human Cell Cultures

Abstract
Human cells treated with trifluoperazine (TFP) or K252a prior to and/or during priming with human interferon-α (HuIFN-α) produce significantly more IFN on induction with poly(rI) · poly(rC) than primed cells in the absence of the drug. Results suggest that calmodulin/protein kinase activity may be involved in priming activity of HuIFN-α.