Histamine, 5-hydroxytryptamine, kinins and the anti-inflammatory activity of human plasma fraction in carrageenan-induced paw oedema in the rat

Abstract

In the carrageenan-induced paw oedema reaction in the rat, the swelling and accumulation of [131I]albumin showed a similar time course over 4 h. Both aspects of the oedema were inhibited by a fraction prepared from human plasma. Treatment of the animals with substances which either deplete the levels or antagonize the actions of either histamine, 5-hydroxytryptamine or kinins showed that these mediators are concerned in the development of rat paw oedema after the injection of either carrageenan or yeast but not with the anti-inflammatory action of the plasma fraction.