On the mechanism of antibody synthesis: a species comparison of L-chains.
- 1 April 1966
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 55 (4), 826-832
- https://doi.org/10.1073/pnas.55.4.826
Abstract
The results of sequence analysis of the N-terminal regions of a number of human and mouse L-chains is presented. Several theories of antibody formation are discussed in the light of these and earlier structural findings. The most reasonable theory of L-chain formation seems to be one in which many genes code for the amino terminal halves of the molecules, while a single gene codes for the remainder. Mechanisms for synthesizing the complete L-chain from the information contained in a "specificity" gene and the "common" gene are discussed.This publication has 19 references indexed in Scilit:
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