Nutritional Megaloblastic Anemia Associated with Sickle Cell States

Abstract
Three patients with megaloblastic anemia complicating sickle cell anemia or sickle cell-hemoglobin C disease are reported. Previously reported cases of megaloblastic anemia in patients with pre-existing hemolytic anemia are reviewed. It is concluded that the megaloblastic blood formation in such patients may be due to excessive need for folic acid or vitamin B12.