DEP: SITE OF INJECTION AND VARIATION IN RESPONSE

Abstract

A study of lethality with different sites of injn. has shown the brain to be the part of the body most sensitive to diisopropylfluorophosphate (OFP), the cause of death being respiratory. Among the other organs, the liver managed the largest doses of DFP with least general effects. Injn. of small amts. of this drug into one common carotid artery produced an adversive syndrome consisting in part of forced circling movements to the side opposite the injn. When artificial respiration was instituted in order to avoid respiratory failure large doses of DFP precipitated grand mal type of brain waves. The subsequent injn. of atropine restored the normal pattern. Atropine given before DFP prevented the development of the grand mal pattern.