CLINICAL MEASUREMENT OF GASTRIC SECRETION: SIGNIFICANCE AND LIMITATIONS
- 1 September 1960
- journal article
- research article
- Published by American College of Physicians in Annals of Internal Medicine
- Vol. 53 (3), 445-461
- https://doi.org/10.7326/0003-4819-53-3-445
Abstract
Indications for gastric analysis, comparison of intubation and tubeless techniques and the procedures of a new routine for the measurement of gastric secretion are presented. The routine suggested consists 1st of testing for the presence or absence of free gastric hydrochloric acid by tubeless gastric analysis with the azure A resin-compound (Diagnex blue). The presence of free acid by this technique usually completes the examination except in an occasional patient in whom the diagnosis of a duodenal ulcer is equivocal. In the latter, the Kay''s basal secretory and augmented histamine procedures are suggested as aids. If tubeless gastric analysis denotes achlorhydria, further investigation is necessary to establish the diagnosis of true achlorhydria or achylia. The presence of uropepsin activity eliminates the diagnosis of true achlorhydria or achylia. The combination of no uropepsin activity and no hydrochloric acid secretion by tubeless gastric analysis with orally administered histalog, as the gastric stimulant, is presumptive evidence of achylia. The Kay augmented histamine intubation technique is the most reliable procedure to detect complete achlorhydria.Keywords
This publication has 10 references indexed in Scilit:
- THE BLOOD SERUM AZURE A LEVEL IN THE DETERMINATION OF GASTRIC ACIDITY BY TUBELESS GASTRIC ANALYSIS1960
- Detection of Achlorhydria by Tubeless Gastric Analysis with Betazole Hydrochloride as the Gastric StimulantNew England Journal of Medicine, 1959
- Gastric Hydrochloric Acid Secretory Response to Orally Administered Betazole HydrochlorideNew England Journal of Medicine, 1959
- Pepsinogen: Its Origins, Secretion and ExcretionPhysiological Reviews, 1957
- PROTEOLYTIC ENZYME ACTIVITY .1. URINARY PROTEOLYTIC ACTIVITY AT PH 1.5 IN ADULTS1957
- Tubeless Gastric Analysis with an Azure a Ion-Exchange CompoundGastroenterology, 1955
- BLOOD PLASMA PEPSINOGEN .1. THE SOURCE, PROPERTIES, AND ASSAY OF THE PROTEOLYTIC ACTIVITY OF PLASMA AT ACID REACTIONS1952
- A SIMPLIFIED METHOD FOR DETERMINING THE EXCRETION RATE OF UROPEPSIN1952
- Determination of Gastric Acidity without Intubation by Use of Cation Exchange Indicator Compounds.Experimental Biology and Medicine, 1950
- A Method for Determining the Renninogen of UrineActa Medica Scandinavica, 1949