Regulation of high affinity choline uptake

Abstract

High affinity uptake of choline, the rate‐limiting, regulatory step for the synthesis of acetylcholine (ACh), was found to be regulated via presynaptic auto‐ and hetero‐receptors. The transport rate was reduced by a muscarinic agonist and neuropeptides, but was significantly enhanced by octopamine. Intracellular messengers, including cyclic nucleotides, appear to modulate the transport activity, apparently by activating specific protein kinases.