Evaluation of Rosette Inhibition Test in Renal Transplantation
- 15 December 1973
- Vol. 4 (5893), 649-651
- https://doi.org/10.1136/bmj.4.5893.649
Abstract
Serial rosette inhibition tests were performed on 11 renal transplant patients in an attempt to predict graft rejection. The rosette inhibition titre was higher in immunosuppressed patients than in normal subjects. The test was of predictive value in only two out of 12 rejection episodes, where a fall in titre to normal levels occurred 48 hours and 24 hours, respectively, before biochemical evidence of rejection. In two further rejection episodes the titre fell at the time of rejection. The titre changes in all tests were small and there were frequent inconsistencies in the results of individual tests. A study of the variables was undertaken, with standardization of the technique, and improvements were made in reading the test. Despite these changes the test was still not sufficiently accurate or reliable to be used as the basis of treatment of rejection episodes.Keywords
This publication has 16 references indexed in Scilit:
- CLASSIFICATION OF THYMUS-DERIVED AND MARROW-DERIVED LYMPHOCYTES BY DEMONSTRATION OF THEIR ANTIGEN-BINDING CHARACTERISTICSThe Journal of Experimental Medicine, 1972
- In Vitro Studies of the Human Response to Organ Allografts: Appearance and Detection of Circulating Activation LymphocytesThe Journal of Immunology, 1971
- Clinical Evaluation of a Rosette Inhibition Test in Renal AllotransplantationBMJ, 1971
- EFFECT OF PROLONGED STORAGE ON THE IMMUNOSUPPRESSIVE POTENCY OF ANTITHYMOCYTE GLOBULINTransplantation, 1971
- LOSS OF IMMUNOSUPPRESSIVE POTENCY OF ANTILYMPHOCYTE SERUM AFTER PROLONGED STORAGETransplantation, 1971
- Surface Antigenic Markers for Distinguishing T and B Lymphocytes in MiceImmunological Reviews, 1971
- ORGAN‐SPECIFIC, ANTIRENAL CELLULAR HYPERSENSITIVITY AFTER KIDNEY TRANSPLANTATIONActa Medica Scandinavica, 1970
- IN VITRO ROSETTE INHIBITION BY ANTIHUMAN ANTILYMPHOCYTE SERUMTransplantation, 1969
- [A new test of activity of antilymphocyte serums: inhibition of the rosette phenomenom].1968
- In vitro Detection of Immunosuppressive Activity of Anti-lymphocyte SeraNature, 1968