Quantitative Analysis of 39 Polybrominated Diphenyl Ethers by Isotope Dilution GC/Low-Resolution MS
- 18 February 2005
- journal article
- Published by American Chemical Society (ACS) in Analytical Chemistry
- Vol. 77 (7), 1979-1987
- https://doi.org/10.1021/ac0484676
Abstract
A GC/low-resolution MS method for the quantitative isotope dilution analysis of 39 mono- to heptabrominated diphenyl ethers was developed. The effects of two different ionization sources, electron impact (EI) and electron capture negative ionization (ECNI), and the effects of their parameters on production of high-mass fragment ions [M − xH − yBr]- specific to PBDEs were investigated. Electron energy, emission current, source temperature, ECNI system pressure, and choice of ECNI reagent gases were optimized. Previously unidentified enhancement of PBDE high-mass fragment ion [M − xH − yBr]- abundance was achieved. Electron energy had the largest impact on PBDE high-mass fragment ion abundance for both the ECNI and EI sources. By monitoring high-mass fragment ions of PBDEs under optimized ECNI source conditions, quantitative isotope dilution analysis of 39 PBDEs was conducted using nine 13C12 labeled PBDEs on a low-resolution MS with low picogram to femtogram instrument detection limits.Keywords
This publication has 27 references indexed in Scilit:
- Brominated flame retardants: cause for concern?Environmental Health Perspectives, 2004
- Rapidly Increasing Polybrominated Diphenyl Ether Concentrations in the Columbia River System from 1992 to 2000Environmental Science & Technology, 2003
- Direct measurement of octanol–water partition coefficients of some environmentally relevant brominated diphenyl ether congenersChemosphere, 2003
- Polybrominated Diphenyl Ethers (PBDEs) in Foodstuffs: Human Exposure through the DietJournal of Agricultural and Food Chemistry, 2003
- Geographical Distribution (2000) and Temporal Trends (1981−2000) of Brominated Diphenyl Ethers in Great Lakes Herring Gull EggsEnvironmental Science & Technology, 2002
- Vapor pressures, aqueous solubilities, and Henry's law constants of some brominated flame retardantsEnvironmental Toxicology and Chemistry, 2002
- Brominated Flame Retardants in Archived Serum Samples from Norway: A Study on Temporal Trends and the Role of AgeEnvironmental Science & Technology, 2002
- An overview of brominated flame retardants in the environmentChemosphere, 2001
- Potent Competitive Interactions of Some Brominated Flame Retardants and Related Compounds with Human Transthyretin in VitroToxicological Sciences, 2000
- STUDIES ON BROMINATED CHEMICALS IN THE ENVIRONMENTAnnals of the New York Academy of Sciences, 1979