An improved method for O-demethylation of codeine

1 January 1977

journal article
research article
Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry

Vol. 20 (1), 165-166
https://doi.org/10.1021/jm00211a037

Abstract

The O-demethylation of codeine was effected by sodium propylmercaptide in dimethylformamide at 125.degree. C to afford morphine in 80% yield. Similar treatment of thebaine was unrewarding.

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