Xanthine-7-Ribosides as Adenosine AlReceptor Antagonists: Further Evidence for Adenosine's Anti Mode of Binding
- 1 February 1990
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 9 (2), 275-291
- https://doi.org/10.1080/07328319008045138
Abstract
The synthesis and A1 adenosine receptor affinity of some xanthine-7-ribosides is described. It appears that these compounds are A, receptor antagonists. The orientation of the ribose moiety, as determined by ′H-NMR spectroscopy and theoretical chemical calculations, is compared with the orientation of the ribose in the agonist adenosine. Implications for the syn vs anti modes of binding to the receptor are discussed.Keywords
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