Protein folding in mitochondria requires complex formation with hsp60 and ATP hydrolysis
- 1 September 1989
- journal article
- Published by Springer Nature in Nature
- Vol. 341 (6238), 125-130
- https://doi.org/10.1038/341125a0
Abstract
Mitochondrial heat-shock protein hsp60 functions in the folding of proteins imported into mitochondria. Folding occurs at the surface of hsp60 in an ATP-mediated reaction, followed by release of the bound polypeptides. We propose that hsp60 catalyses protein folding.Keywords
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