Some effects of Pco2 and pH on nerve tissue

Abstract

1 Rat phrenic nerve preparations were used in vitro to study action potential amplitude and nerve conduction time under varying conditions of Pco₂ and sodium bicarbonate concentration in the surrounding Krebs solution. 2 A correlation was found between action potential amplitude and pH but not between action potential amplitude and Pco₂. 3 A better correlation was found between conduction time and pH than between conduction time and Pco₂.