Leukemia Virus Activation in Chronic Allogeneic Disease
- 1 December 1970
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 67 (4), 1914-1917
- https://doi.org/10.1073/pnas.67.4.1914
Abstract
Young adult (BALB/c × A/J)F1 hybrid mice have no detectable leukemia viruses. When inoculated with parental BALB/c spleen lymphoid cells, also free of detectable virus, leukemia viruses rapidly become activated in the injected host. Because of similarities between such graft-induced allogeneic disease and spontaneous autoimmunity, it is proposed that autoimmune reactions may activate latent viruses.Keywords
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