Hemolytic Anemia Complicating Aortic-Valve Surgery

Abstract

HEMOLYTIC anemia has occasionally been reported as complicating various open-heart surgical procedures performed in laboratory animals¹ and human patients.^{2 3 4} These cases have been characterized by destruction of erythrocytes through mechanical means. We have recently encountered 7 cases of acquired hemolytic anemia after aortic-valve surgery that did not appear to result solely from mechanical breakdown of erythrocytes. The association of positive serologic tests and a characteristic clinical pattern suggests a previously undescribed syndrome. The purpose of the present report is to outline the clinical nature of this state and to indicate a possible autoimmune pathogenesis for the hemolytic process.Case Reports . . .