A Serum Protein Associated with Chromatin of Cultured Fibroblasts
- 27 February 1976
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 191 (4229), 869-870
- https://doi.org/10.1126/science.56037
Abstract
Antibodies to chromatin proteins from human and mouse fibroblasts which have been cultured for more than 25 generations with heterologous serum show specificity for a homologous alpha-serum protein. These results indicate that among the chromatin-associated proteins there is one (or more) which has extensive structural similarity to a serum protein. This is the first direct evidence that a serumlike protein or proteins could be chromatin associated in vivo, as has been suggested by experiments showing in vitro interaction between DNA and certain serum proteins.Keywords
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