EFFECT OF PROLONGED AND NEONATAL CAPSAICIN TREATMENTS ON THE SUBSTANCE P IMMUNOREACTIVE NERVES IN THE RABBIT EYE AND SPINAL CORD
- 1 October 1981
- journal article
- Published by Wiley in Acta Ophthalmologica
- Vol. 59 (5), 737-746
- https://doi.org/10.1111/j.1755-3768.1981.tb08740.x
Abstract
Substance-P (SP) immunoreactivity was demonstrated in the rabbit eye and spinal cord using monoclonal SP antibody and an indirect immunofluorescence technique. Norves containing SP immunoreactive material were found in the cornea, iris and ciliary body of which the iridic sphincter had the densest innervation. Neither prolonged subcutaneous treatment (up to 280 mg/kg) augmented by intracameral capsaicin injection nor neonatal treatment with drug 70 mg/kg eliminated this immunoreactivity, though both blocked the miotic effect of intracameral SP. It is concluded that capsaicin is not specific SP depleting agent but rather a neurotocic substance that affects noxious pathways and probably prevents the release of the SP retained by the nerve following the treatment used.Keywords
This publication has 18 references indexed in Scilit:
- Ocular responses to antidromic trigeminal stimulation, intracameral prostaglandin E1 and E2, capsaicin and substance PActa Physiologica Scandinavica, 1981
- Immunoreactivity for substance P in the gasserian ganglion, ophthalmic nerve and anterior segment of the rabbit eyeJournal of Molecular Histology, 1981
- Effects of capsaicin on nociceptive heat, pressure and chemical thresholds and on substance P levels in the ratBrain Research, 1980
- Substance P and pain: an updatingTrends in Neurosciences, 1980
- Substance P levels in normal and sensorily denervated rabbit eyesExperimental Eye Research, 1980
- Neurotoxic action of capsaicin on spinal substance P neuronsBrain Research, 1980
- Substance P: Release on trigeminal nerve stimulation, effects in the eyeActa Physiologica Scandinavica, 1979
- Pharmacologically induced selective degeneration of chemosensitive primary sensory neuronesNature, 1977
- INFLUENCE OF THE FIFTH CRANIAL NERVE ON THE INTRA-OCULAR PRESSURE OF THE RABBIT EYEBritish Journal of Ophthalmology, 1957
- Uber die Beziehung der sensiblen Nervenendigungen zum EntzündungsvorgangNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1910