LOCAL TISSUE REACTIONS TO CORTISONE AND HYDROCORTISONE (COMPOUND F) IN MAN

Abstract

WE HAVE reported previously our investigative studies concerning the detection of compound F crystals injected into the skin; the histopathology of the reactions of normal and pathologic skin to compound F; some investigative studies on the eczematous, tuberculin, and arthropod bite reactions in the skin, and the oral use of compound F in skin diseases.¹ We should like to report in this paper the results of a study of the local therapeutic effect of compound F in 460 patients observed during the past two years. Compound F was given by needle and syringe, by the hypospray® jet injection apparatus, in various ointment vehicles, and as a suspension in various solutions. In 160 patients, compound F acetate and the free alcohol of compound F were given orally. These patients will not be included in this report. The results with the ointments in 135 patients given compound F acetate