Effect of Growth Hormone and Oxytocin Upon Milk Yield in the Lactating Rat.
- 1 January 1959
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 100 (1), 158-161
- https://doi.org/10.3181/00379727-100-24558
Abstract
We have investigated the effect of growth hormone (GH) and oxytocin alone, and in combination, upon lactation in the rat. Amount of milk obtained by a litter of 6 during 30 minutes nursing on day 14 postpartum, expressed as percent litter body weight, was used as the index of response. Control yields averaged 3.8% with normal distribution. Removal of milk with aid of 0.1 USP unit/kg oxytocin intravenously resulted in 50% higher yield with more uniformity among individual values. GH injected subcutaneously from days 7-13 at dose of 1 mg/rat/day evoked a 41.1% increase in milk yield. Yields obtained in GH-treated lactating rats with aid of oxytocin were greater and mope uniform than with GH or oxytocin alone. GH had no effect upon pituitary, thyroid or adrenal weight/100 g body weight. GH caused a significant increase in percent weight gain of mothers but not their litters.Keywords
This publication has 3 references indexed in Scilit:
- Effects of Growth Hormone on Lactation and Body Growth of Parturient Rats.Experimental Biology and Medicine, 1957
- Estimation of Amount of Oxytocin Released as Result of Nursing Stimuli in Lactating Rat.Experimental Biology and Medicine, 1957
- Ergotamine, Oxytocin and Milk Let-Down in Lactating Rat.Experimental Biology and Medicine, 1956