Fluorine‐19 NMR imaging of glucose metabolism
- 1 March 1988
- journal article
- research article
- Published by Wiley in Magnetic Resonance in Medicine
- Vol. 6 (3), 307-313
- https://doi.org/10.1002/mrm.1910060309
Abstract
Metabolic imaging reflecting glucose metabolism in the glycolytic and aldose reductase sorbitol (ARS) pathways was performed noninvasively in rat using fluorinated glucose analogs, 2-fluoro-2-deoxy-D-glucose (2-FDG) or 3-fluoro-3-deoxy-D-glucose (3-FDG), and fluorine-19 (19F) nuclear magnetic resonance (NMR) imaging. I9F images of 2-FDG-6-phosphate, a main metabolite of 2-FDG in the glycolytic pathway, showed high glucose utilization in the brain, spinal cord, and heart. Images of 3-fluoro-3-deoxy-D-sorbitol (3-FDSL), a main metabolite of 3-FDG in the ARS pathway, demonstrated the heterogeneous nature of the spatial distribution of aldose reductase activities, being highest in the brain and lens. The extremely low toxicity of 3-FDG indicates promise for clinical application of 3-FDG NMR imaging. © 1988 Academic Press, Inc.This publication has 18 references indexed in Scilit:
- Noninvasive Demonstration of In Vivo 3-Fluoro-3-Deoxy-D-Glucose Metabolism in Rat Brain by19F Nuclear Magnetic Resonance Spectroscopy: Suitable Probe for Monitoring Cerebral Aldose Reductase ActivitiesJournal of Neurochemistry, 1987
- Noninvasive evaluation of effects of an aldose reductase inhibitor in rat brain by 19F FDG NMR spectroscopyMagnetic Resonance in Medicine, 1987
- In vivo spectroscopic magnetic resonance imaging using estimation theoryMagnetic Resonance in Medicine, 1986
- Noninvasive In Vivo Demonstration of 2‐Fluoro‐2‐Deoxy‐d‐Glucose Metabolism Beyond the Hexokinase Reaction in Rat Brain by 19F Nuclear Magnetic Resonance SpectroscopyJournal of Neurochemistry, 1986
- Aldose reductase inhibition in the prevention and treatment of diabetes-associated complicationsAmerican Journal Of Medicine, 1985
- In Vivo 19F NMR Imaging of the Cardiovascular SystemJournal of Computer Assisted Tomography, 1985
- An efficient, highly homogeneous radiofrequency coil for whole-body NMR imaging at 1.5 TJournal of Magnetic Resonance (1969), 1985
- Chemical-shift-resolved tomography using frequency-selective excitation and suppression of specific resonancesJournal of Magnetic Resonance (1969), 1984
- THE [14C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT1Journal of Neurochemistry, 1977
- Kinetics of blood-brain barrier transport of hexosesBiochimica et Biophysica Acta (BBA) - Biomembranes, 1975