Second-harmonic optical coherence tomography
Open Access
- 14 May 2004
- journal article
- research article
- Published by Optica Publishing Group in Optics Letters
- Vol. 29 (10), 1090-1092
- https://doi.org/10.1364/ol.29.001090
Abstract
Second-harmonic optical coherence tomography, which uses coherence gating of second-order nonlinear optical responses of biological tissues for imaging, is described and demonstrated. Femtosecond laser pulses were used to excite second-harmonic waves from collagen harvested from rat tail tendon and a reference nonlinear crystal. Second-harmonic interference fringe signals were detected and used for image construction. Because of the strong dependence of second-harmonic generation on molecular and tissue structures, this technique imparts contrast and resolution enhancement to conventional optical coherence tomography.Keywords
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