Targeting Oligosaccharides and Glycoconjugates Using Superselective Binding Scaffolds
Open Access
- 28 May 2020
- journal article
- research article
- Published by Wiley in Advanced Functional Materials
- Vol. 30 (31), 2002298
- https://doi.org/10.1002/adfm.202002298
Abstract
Recognition of oligosaccharides is associated with very limited specificity due to their strong solvation in water and the high degree of subtle structural variations between them. Here, oligosaccharide recognition sites are created on material surfaces with unmatched, binary on–off binding behavior, sharply discriminating a target oligosaccharide over closely related carbohydrate structures. The basis for the superselective binding behavior relies on the highly efficient generation of a pure, high order complex of the oligosaccharide target with synthetic carbohydrate receptor sites, in which the spatial arrangement of the multiple receptors in the complex is preserved upon material surface incorporation. The synthetic binding scaffolds can easily be tailored to recognize different oligosaccharides and glycoconjugates, opening up a realm of possibilities for their use in a wide field of applications, ranging from life sciences to diagnostics.Keywords
Funding Information
- European Research Council (614787)
- Medical Research Council (MC_PC_15032)
- Prostate Cancer UK (RIA17‐ST2‐020)
- Engineering and Physical Sciences Research Council (EP/K027263/1)
- H2020 European Research Council
This publication has 30 references indexed in Scilit:
- Selective sensing of saccharides using simple boronic acids and their aggregatesChemical Society Reviews, 2013
- Glycans as cancer biomarkersBiochimica et Biophysica Acta (BBA) - General Subjects, 2011
- Cancer vaccines and carbohydrate epitopesVaccine, 2011
- Designing super selectivity in multivalent nano-particle bindingProceedings of the National Academy of Sciences, 2011
- Glycoproteomics and clinical applicationsProteomics – Clinical Applications, 2010
- Benzoboroxoles as Efficient Glycopyranoside-Binding Agents in Physiological Conditions: Structure and Selectivity of Complex FormationThe Journal of Organic Chemistry, 2008
- Functional roles of N‐glycans in cell signaling and cell adhesion in cancerCancer Science, 2008
- The glycans of horseradish peroxidaseCarbohydrate Research, 1996
- Boronic acids as fructose sensors. Structure determination of the complexes involved using 1 J CC coupling constantsJournal of the Chemical Society, Perkin Transactions 2, 1996