Bladder-Surface Glycosaminoglycans: An Efficient Mechanism of Environmental Adaptation
- 9 May 1980
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 208 (4444), 605-607
- https://doi.org/10.1126/science.6154316
Abstract
The transitional epithelium of the urinary bladder secretes and binds to its surface a glycosaminoglycan than inhibits the adherence of bacteria. Synthetic sulfonated glycosaminoglycans instilled intraluminally into bladders whose natural mucin layer has been removed are as effective as the natural mucin in preventing bacterial adherence. It also appears that adherence of calcium and protein is reduced in the presence of both the natural mucin layer and the synthetic sulfonated glycosaminoglycan sodium pentosanpolysulfate, suggesting that the antiadherence activity of both natural and synthetic surface glycosaminoglycans in the bladder extends to the molecular and ionic levels.Keywords
This publication has 5 references indexed in Scilit:
- The Synthesis of Glycosaminoglycans by Cultures of Corneal Stromal Cells from Patients with KeratoconusJournal of Clinical Investigation, 1979
- The protective effect of heparin in experimental bladder infectionJournal of Surgical Research, 1978
- Role of surface mucin in primary antibacterial defense of bladderUrology, 1977
- Enzymatic degradation of heparin-related mucopolysaccharides from the surface of endothelial cell culturesBiochimica et Biophysica Acta (BBA) - General Subjects, 1975
- Sulfated mucopolysaccharide synthesis and secretion in endothelial cell culturesExperimental Cell Research, 1973