ALIMENTARY TRACT IN DISSEMINATED SCLERODERMA WITH EMPHASIS ON SMALL BOWEL
- 1 July 1954
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Internal Medicine
- Vol. 94 (1), 61-81
- https://doi.org/10.1001/archinte.1954.00250010067006
Abstract
THE PROTEAN nature of disseminated scleroderma has been thoroughly documented.* In the discussion of alimentary tract involvement, the esophagus has been the focus of most attention. The changes in the remainder of the gastrointestinal tract have not been adequately stressed or completely described. Review of the literature indicates that at least 21 cases with either roentgenologic or pathologic evidence of intestinal involvement by scleroderma have been recorded in sufficient detail to be analyzed.f Although 13 of these cases were subjected to autopsy, there have been few detailed descriptions of the histologic changes in the small intestine and even fewer adequate illustrations. On the whole, the findings were said to consist of replacement by dense collagen of the submucosa and at times of the muscularis, associated with atrophy and degenerative changes, particularly of the smooth muscle. The onset of the disease occurred prior to the age of 40 in about two-thirdsKeywords
This publication has 8 references indexed in Scilit:
- Progressive Systemic Sclerosis with Dominating Gastro-Intestinal DisturbancesActa Medica Scandinavica, 2009
- Progressive Systemic Sclerosis (Scleroderma)New England Journal of Medicine, 1953
- TREATMENT OF DIFFUSE PROGRESSIVE SCLERODERMA1953
- CORTISONE-TREATED SCLERODERMAJAMA, 1951
- CLINICAL STUDY OF VISCERAL LESIONS AND ENDOCRINE DISTURBANCES IN EIGHT CASES OF DIFFUSE SCLERODERMAAnnals of Internal Medicine, 1951
- THE PULMONARY MANIFESTATIONS OF SCLERODERMA: AN ANATOMIC-PHYSIOLOGICAL CORRELATIONAnnals of Internal Medicine, 1950
- SCLERODERMA OF THE INTESTINAL TRACT - 1ST REPORT OF A FATAL CASE1948
- THE CLINICAL SIGNIFICANCE OF THE LOW OR "FLAT" ORAL GLUCOSE TOLERANCE CURVEAnnals of Internal Medicine, 1941