THE EFFECT OF CYCLOSPORIN-A ON PERIPHERAL-BLOOD T-CELL SUB-POPULATIONS IN RENAL-ALLOGRAFTS
- 1 January 1982
- journal article
- research article
- Vol. 47 (2), 445-448
Abstract
Treatment with cyclosporin A (CyA) produces a reversal of the normal ratio of OKT4+ (inducer type) to OKT8+ (suppressor-cytotoxic type) cells so that renal allograft recipients on CyA alone develop a 4-fold increase in the absolute number of circulating OKT8 positive cells. Conventional immunosuppression with azathioprine and prednisolone reduces both populations of T cells without altering the ratio of OKT4+ to OKT8+ cells. This effect of CyA may help to explain its action as an immunosuppressive agent.This publication has 17 references indexed in Scilit:
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