Susceptibility of rheumatoid and nonrheumatoid synovial cells to antibody‐dependent cell‐mediated cytotoxicity
- 31 December 1977
- journal article
- research article
- Published by Wiley in Arthritis & Rheumatism
- Vol. 21 (1), 97-106
- https://doi.org/10.1002/art.1780210116
Abstract
Fibroblastic cells derived from rheumatoid (RA) and nonrheumatoid (N‐RA) synovial tissue (synovial cells) were used as targets in assays of antibody‐dependent cell‐mediated cytotoxicity (ADCC). Synovial cells that had been pretreated with human alloantisera were rapidly lysed by normal human blood mononuclear cells. RA and N‐RA synovial cells were equally susceptible to ADCC under these assay conditions. Antibody to autologous synovial cells was not detected in sera from 10 patients with RA by this method of assay.This publication has 34 references indexed in Scilit:
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