THE PRESSOR RESPONSE OF NORMAL AND HYPERTENSIVE DOGS TO RENIN AND ANGIOTONIN

Abstract

Induction of exptl. renal hypertension in dogs does not increase the pressor response to angiotonin. On the other hand, in such animals renin causes somewhat greater responses. The increased response to renin is probably due to greater formation of angiotonin from combination of renin and renin-activator, and is not the result of increased sensitivity of the vascular system of hypertensive animals.