Intercapillary Glomerulosclerosis

Abstract

IN 1936 a small series of cases was reported by Kimmelstiel and Wilson¹ showing a conspicuous correlation between a syndrome of diabetes, nephrotic edema, gross albuminuria and hypertension and a peculiar type of intercapillary sclerosis of glomeruli. The nature of this investigation, taking its origin from systematic analysis of a large volume of autopsy material, precluded a specific detailed study of clinical features. The relatively scant clinical information was merely sufficient to emphasize the significance of the histologic findings. A large number of similar cases have been reported during the last twelve years, and with them a wealth of clinical . . .